■ Yonsei Research in Media / Yonsei Cancer Center and Novartis to Co-Develop Cancer Drugs As the first instance for South Korean hospitals, Yonsei Cancer Center partners with the multinational pharmaceutical company to develop new drug from the beginning stage The Yonsei Cancer Center has joined with multinational pharmaceutical company Novartis to develop new cancer treatment drugs. It is the first instance of a South Korean hospital partnering with a multinational pharmaceutical company as early in the process of drug development as the beginning stage of identifying new drug candidates. Yonsei University Health System President & CEO Do-Heum Yoon announced last August that Novartis hadRead More →

■ Medicine / New Pathway from Liver Cirrhosis to Liver Cancer Discovered A research team led by Yonsei researchers has demonstrated that a certain activated signal promotes the incidence of liver cancer from the initial stage Patients with liver cirrhosis is a typical risk group of liver cancer. Fibrosis progresses by constant liver damage, and with the loss of liver functions a severe form of liver fibrosis is diagnosed as cirrhosis. Patients with liver cirrhosis have a very high chance of liver cancer. TGF-β signaling is known as a major factor involved in liver cirrhosis, and active in most patients with cirrhosis. Ironically, TGF-β isRead More →

■ Medicine / Which Tastes Sweeter, Candy or Jelly? A Yonsei research team has proved that food hardness acts as a determinant of food preference. Given the same sugar content, which of hard candy or soft jelly is felt to be sweeter? A study reported that preference for food with same taste may vary according to its hardness. The research team led by Professor Seok Jun Moon(left) from the Department of Oral Biology at Yonsei University College of Dentistry recently published a study on the ‘clarification of the mutual relationship between food hardness and taste cognition’ on Nature Communications, a sister journal of Nature. TheRead More →

■ Medicine / Genetic Variant that Increases the Risk of Breast and Ovarian Cancer in Korean Population Discovered Yonsei researchers have identified a novel Korean-specific mutation that is expected to contribute in detecting and preventing relevant cancers. A genetic cancer clinic research team, including Professor Ji Soo Park from the Cancer Prevention Center at the Yonsei Cancer Center and Professor Seung Tae Lee from the Department of Laboratory Medicine at the Severance Hospital, has discovered that the risk of breast cancer and ovarian cancer increases in Koreans with c.5339T>C p.Leu1780Pro variant (hereinafter referred to as L1780P variant). BRCA1 , 2 genetic mutation is a majorRead More →

■ Life Sciences / Novel Tumor-Suppressive Signaling Mechanism Identified A collaborative research team gets closer to the possibility of developing a powerful anticancer. This interesting study published in July 2017 in Nature Cell Biology identifying a novel tumor-suppressive cellular signaling mechanism has been conducted in collaboration between laboratories of Professor-Hyun Woo Park (Yonsei University) and Kun-Liang Guan (University of California San Diego, USA). The Hippo pathway has gained tremendous interest over the last decade because of its ability to control organ size and tissue homeostasis, and deregulation of this pathway leads to cancer. Inactivation of core Hippo pathway kinases leads to the activation of theRead More →

■ Life Sciences / A Novel Method of Active Site Redesign for Amine-based Drug Production The method developed by a team led by Prof. Jong-Shik Shin is expected to initiate the establishment of a technique for obtaining optically active amines, which was previously impossible using naturally occurring enzymes. Pain generally occurs due to tissue damage and helps humans to recognize their physical problems. If patients do not feel pain when their bodies were damaged, it can cause serious problems including death due to delayed treatment. On other hand, the excessive activation of pain-related nerves in certain individuals can cause them to suffer from a diseaseRead More →

■ Engineering & Technology / New Thinner, Sensorless Core Display Technology is Developed The next-generation device that can take the roles of both the sensor and display has been developed by a Yonsei research team. A research team led by Professor Cheolmin Park (Yonsei University) announced that they developed a new sensorless core display technology that would immediately detect conductive biometric information, such as fingerprints, and show on the screen. While the current OLED-based sensor display separates the sensor from the display, the OLEB, developed by the team recently, has one device that takes the roles of both the sensor and display. This simplifies theRead More →

■ Natural Sciences / From Gondwana-land to Far East Asia! An investigation tracking the tectonic evolution of the South Korean Peninsula during the Paleozoic Period, over 500 million years ago. The earth is old. Really old. So old, that it is difficult to imagine the timescales that its processes work over. Yes, these are all clichéd statements that have been rehashed in every geology book ever, but it’s always good to have that reminder as we continue to delve into the history of our home planet. There are few convenient clues, like coins or tree rings, to give us insight into the absolute age andRead More →

■ Natural Sciences / Getting to Know Virgo: a Date with Galactic Evolutionary History Researchers use phase-space location with hydrogen gas morphology to trace galaxy interactions. In the continuing quest to understand the internal workings of our cosmos, Dr. Aeree Chung from Yonsei University with other researchers from around the world, attempted to create tools for projecting galaxy trajectories and star formations using only imaging of hydrogen gas. Hydrogen is the most common element in the universe and can be easily visualized using a wide variety of tools. In this case, the researchers focused on HI, which is the chemical symbol for the neutral formRead More →

■ Natural Sciences / Artificial Ion Transporters: Cell Death by Sodium Chloride Ions Researchers from Yonsei University reveal the role of synthetic ion transporters in cell death. Professor Injae Shin (Department of Chemistry at Yonsei University, Korea) in collaboration with Professor Philip Gale (current address: School of Chemistry at the University of Sydney, Australia), and Professor Jonathan Sessler (Department of Chemistry at the University of Texas at Austin, USA) demonstrated for the first time that squaramide-based ion transporters promote cancer cell death by disrupting autophagy (self-eating) and inducing apoptosis (self-killing). Cellular ion concentrations are tightly regulated by natural channels/transporters for sustaining life processes. Synthetic anionRead More →