A Novel Method of Active Site Redesign for Amine-based Drug Production

■ Life Sciences / A Novel Method of Active Site Redesign for Amine-based Drug Production The method developed by a team led by Prof. Jong-Shik Shin is expected to initiate the establishment of a technique for obtaining optically active amines, which was previously impossible using naturally occurring enzymes. Professor Jong-Shik Shin from the Department of Biotechnology at Yonsei University and his team have developed an efficient computational strategy for redesigning the reaction pathway of transaminase. This strategy will allow the development of enzyme variants engineered to produce optically active amines, which are pharmaceutically valuable intermediates. Optical isomers refer to a set of two molecules that … Continue reading A Novel Method of Active Site Redesign for Amine-based Drug ProductionRead More →